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当前位置:首页产品中心细胞因子及蛋白细胞因子Mouse Oncostatin M Protein重组小鼠肿瘤抑制素M(OSM)

重组小鼠肿瘤抑制素M(OSM)
产品简介:

商品信息产品英文名称MouseOncostatinMProtein产品中文名称重组小鼠肿瘤抑制素M(OSM)别名OSM

产品型号:Mouse Oncostatin M Protein

更新时间:2025-03-14

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产品介绍

商品信息

产品英文名称 Mouse Oncostatin M Protein
产品中文名称 重组小鼠肿瘤抑制素M(OSM)
别名 OSM; OS-M; Oncostatin M

商品属性

标签无标签
表达宿主大肠杆菌
种属小鼠
序列氨基酸序列来源于:重组小鼠肿瘤抑制素M(OSM) (P53347) (Ala24-Arg206) 表达的蛋白片段。
活性Testing in Progress
蛋白长度重组小鼠肿瘤抑制素M(OSM)由183个氨基酸组成,预测分子量为20.39 KD。
纯度> 99% ,使用SDS-PAGE检测
特点&优势通过LAL法测定,每微克蛋白里内毒素含量<1.0>
产品形式冻干粉,冻干缓冲液为无菌的20 mM Tris,150 mM NaCl,pH 7.4。
基因ID18413
蛋白序列链接/uniprotkb/P53347/entry
使用中注意事项开盖使用前,请先离心。本产品为冻干粉,推荐用该产品配套的Reconstitution Buffer进行复溶,且浓度不低于100 µg/mL。客户可根据后续的实验需求,进行进一步的稀释。
保存建议本产品为冻干粉形式,建议:将冻干粉产品保存于-20℃以下的干燥环境中。本产品溶解之后,可在4℃保存2-7天,长期使用请置于-20℃以下。为长期保存,推荐添加载体蛋白(0.1% HAS/BSA或11%FBS),并酌情分装保存,避免反复冻融。
运输条件冰袋运输(蓝冰)
警告本文列出的产品仅供研究使用,不适用于人类或临床诊断。我们产品所推荐应用,不是建议使用我们的产品去违反任何或许可证。对于使用本产品可能发生的侵权或其他违规行为,我们不承担任何责任。

附加信息

背景Oncostatin M (OSM) is a glycoprotein belonging to the interleukin-6 family of cytokines that has functions mainly in cell growth. Oncostatin M (OSM) is considered as a pleiotropic cytokine that signals through cell surface receptors typeⅠand typeⅡ both of which share the similarity of containing protein gp130 and takes part in many bio metabolism processes including liver development, hematopoiesis, inflammation, bone formation, and destruction and possibly CNS development. Oncostatin M (OSM) was previously identified by its ability to inhibit the growth of cells from melanoma and other solid tumors. It also has been reported that OSM, like LIF, IL-6, and G-CSF, can inhibit the proliferation of murine M1 myeloid leukemic cells and can induce their differentiation into macrophage-like cells. The human form of OSM is insensitive between pH2 and 11 and resistant to heating for one hour at 56 degrees but is not stable at 90 degrees. The human OSM is produced as a precursor containing 252 amino acids, whose first 25 amino acids function as a secretory signal peptide and which on removal yields the soluble 227 amino acid pro-OSM. Removal of the C-terminal most 31 amino acids produces the fully active 196 residue form.

图片及说明

Fig.Mouse Oncostatin M (OSM) Protein

Fig.Mouse Oncostatin M (OSM) Protein

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