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产品型号:Human IL-17A Protein
更新时间:2025-06-23
厂商性质:生产厂家
访问量:149
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产品英文名称 | Human IL-17A Protein |
产品中文名称 | 17A(IL-17A) |
别名 | interleukin 17A, CTLA-8, IL17, IL17A |
表达宿主 | 大肠杆菌 |
种属 | 人 |
序列 | 氨基酸序列来源于:人IL-17A (Ile20-Ala155) (Q16552) 表达的蛋白片段。 |
活性 | Testing in progress. |
蛋白长度 | 重组人IL-17A由136个氨基酸组成,预测分子量为15.7 KD。 |
纯度 | > 98% ,使用SDS-PAGE检测 |
特点&优势 | 通过LAL法测定,每微克蛋白里内毒素含量<0.1>0.1> |
产品形式 | 冻干粉,冻干缓冲液为无菌的20 mM Tris,50 mM NaCl,pH 8.0。 |
基因ID | 3605 |
蛋白序列链接 | /uniprotkb/Q16552/entry#sequences |
使用中注意事项 | 开盖使用前,请先离心。本产品为冻干粉,推荐用该产品配套的Reconstitution Buffer进行复溶,且浓度不低于100 µg/mL。客户可根据后续的实验需求,进行进一步的稀释。 |
保存建议 | 本产品为冻干粉形式,建议:将冻干粉产品保存于-20℃以下的干燥环境中。本产品溶解之后,可在4℃保存2-7天,长期使用请置于-20℃以下。为长期保存,推荐添加载体蛋白(0.1% HSA或者BSA),并酌情分装保存,避免反复冻融。 |
运输条件 | 冰袋运输(蓝冰) |
警告 | 本文列出的产品仅供研究使用,不适用于人类或临床诊断。我们产品所推荐应用,不是建议使用我们的产品去违反任何或许可证。对于使用本产品可能发生的侵权或其他违规行为,我们不承担任何责任。 |
背景 | Interleukin-17A (IL-17A), also known as CTLA-8, belongs to the IL-17 cytokine family. IL-17A is expressed in memory Th17 cells and is a product of memory CD4+T cells. In addition to Th17 cells, IL-17A can also be produced by various immune cells, including CD8+T cells γδ T cells, natural killer T (NKT) cells, monocytes, and neutrophils. IL-17A plays a crucial role in the host's defense mechanisms against many bacterial and fungal pathogens, as well as in allergic and autoimmune responses. IL-17A plays a role in viral infection by promoting neutrophil inflammation. IL-17A is a homodimeric cytokine with similar biological activity to IL-17F. IL-17A and IL-17RA have high affinity binding, and IL-17RA is essential for the biological activity of IL-17A. IL-17A cannot bind to T cells, B cells, and myeloid cells lacking IL-17RA. IL-17A is associated with various autoimmune diseases, such as rheumatoid arthritis, multiple sclerosis, inflammatory bowel disease, asthma, and psoriasis. IL-17A also plays a pathogenic role in cancer. During tumor development, IL-17A recruits bone marrow-derived suppressor cells (MDSCs) to suppress anti-tumor immunity. IL-17A also promotes tumor growth in vivo by inducing IL-6. |
Fig.Human IL-17A Protein