15527492905
15527492905
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产品型号：Human IGF1 Protein
更新时间：2025-06-23
厂商性质：生产厂家
访问量：116
服务热线86-027-59716789
| 产品英文名称 | Human IGF1 Protein |
| 产品中文名称 | 样生长因子1（IGFI） |
| 别名 | Long R3 IGF-I; Insulin-like growth factor I; MGF; Somatomedin-C; IBP1 |
| 标签 | 无标签 |
| 表达宿主 | 大肠杆菌 |
| 种属 | 人 |
| 序列 | 氨基酸序列来源于：样生长因子1（IGFI) (P05019-1) (Gly49-Ala118) 表达的蛋白片段。 |
| 活性 | 通过其诱导MCF-7细胞增殖的能力来测定。该效应的ED50为76.41 ng/mL。 |
| 蛋白长度 | 样生长因子1（IGFI） 由71个氨基酸组成，预测分子量为7.8 KD。 |
| 纯度 | > 99% ，使用SDS-PAGE检测 |
| 特点&优势 | 通过LAL法测定，每微克蛋白里内毒素含量<1.0> |
| 产品形式 | 冻干粉，冻干缓冲液为无菌的20 mM Tris，150 mM NaCl，pH 7.4。 |
| 基因ID | 3479 |
| 蛋白序列链接 | /uniprotkb/P05019/entry#P05019-1 |
| 使用中注意事项 | 开盖使用前，请先离心。本产品为冻干粉，推荐用该产品配套的Reconstitution Buffer进行复溶，且浓度不低于100 µg/mL。客户可根据后续的实验需求，进行进一步的稀释。 |
| 保存建议 | 本产品为冻干粉形式，建议：将冻干粉产品保存于-20℃以下的干燥环境中。本产品溶解之后，可在4℃保存2-7天，长期使用请置于-20℃以下。为长期保存，推荐添加载体蛋白（0.1% HAS/BSA或13%FBS），并酌情分装保存，避免反复冻融。 |
| 运输条件 | 冰袋运输（蓝冰） |
| 警告 | 本文列出的产品仅供研究使用，不适用于人类或临床诊断。我们产品所推荐应用，不是建议使用我们的产品去违反任何或许可证。对于使用本产品可能发生的侵权或其他违规行为，我们不承担任何责任。 |
| 背景 | IGF I, also known as Mechano Growth Factor, somatomedin-C, IGF-I, and IGF1, is a secreted protein that belongs to the insulin family. The insulin family, comprised of insulin, relaxin, insulin-like growth factors I and II ( IGF-I and IGF-II ), and possibly the beta-subunit of 7S nerve growth factor, represents a group of structurally related polypeptides whose biological functions have diverged. The IGFs, or somatomedins, constitute a class of polypeptides that have a key role in pre-adolescent mammalian growth. IGF-I expression is regulated by GH and mediates postnatal growth, while IGF-II appears to be induced by placental lactogen during prenatal development. IGF1 / IGF-I may be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. IGF1 / IGF-I stimulates glucose transport in rat bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also about enhancing glucose uptake. Defects in IGF1 / IGF-I are the cause of insulin-like growth factor I deficiency (IGF1 deficiency) which is an autosomal recessive disorder characterized by growth retardation, sensorineural deafness, and mental retardation. |
Fig.Human IGF1 Protein
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