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产品型号:Human IGF1 Protein
更新时间:2025-03-13
厂商性质:生产厂家
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产品英文名称 | Human IGF1 Protein |
产品中文名称 | 样生长因子1(IGFI) |
别名 | Long R3 IGF-I; Insulin-like growth factor I; MGF; Somatomedin-C; IBP1 |
标签 | 无标签 |
表达宿主 | 大肠杆菌 |
种属 | 人 |
序列 | 氨基酸序列来源于:样生长因子1(IGFI) (P05019-1) (Gly49-Ala118) 表达的蛋白片段。 |
活性 | 通过其诱导MCF-7细胞增殖的能力来测定。该效应的ED50为76.41 ng/mL。 |
蛋白长度 | 样生长因子1(IGFI) 由71个氨基酸组成,预测分子量为7.8 KD。 |
纯度 | > 99% ,使用SDS-PAGE检测 |
特点&优势 | 通过LAL法测定,每微克蛋白里内毒素含量<1.0>1.0> |
产品形式 | 冻干粉,冻干缓冲液为无菌的20 mM Tris,150 mM NaCl,pH 7.4。 |
基因ID | 3479 |
蛋白序列链接 | /uniprotkb/P05019/entry#P05019-1 |
使用中注意事项 | 开盖使用前,请先离心。本产品为冻干粉,推荐用该产品配套的Reconstitution Buffer进行复溶,且浓度不低于100 µg/mL。客户可根据后续的实验需求,进行进一步的稀释。 |
保存建议 | 本产品为冻干粉形式,建议:将冻干粉产品保存于-20℃以下的干燥环境中。本产品溶解之后,可在4℃保存2-7天,长期使用请置于-20℃以下。为长期保存,推荐添加载体蛋白(0.1% HAS/BSA或13%FBS),并酌情分装保存,避免反复冻融。 |
运输条件 | 冰袋运输(蓝冰) |
警告 | 本文列出的产品仅供研究使用,不适用于人类或临床诊断。我们产品所推荐应用,不是建议使用我们的产品去违反任何或许可证。对于使用本产品可能发生的侵权或其他违规行为,我们不承担任何责任。 |
背景 | IGF I, also known as Mechano Growth Factor, somatomedin-C, IGF-I, and IGF1, is a secreted protein that belongs to the insulin family. The insulin family, comprised of insulin, relaxin, insulin-like growth factors I and II ( IGF-I and IGF-II ), and possibly the beta-subunit of 7S nerve growth factor, represents a group of structurally related polypeptides whose biological functions have diverged. The IGFs, or somatomedins, constitute a class of polypeptides that have a key role in pre-adolescent mammalian growth. IGF-I expression is regulated by GH and mediates postnatal growth, while IGF-II appears to be induced by placental lactogen during prenatal development. IGF1 / IGF-I may be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. IGF1 / IGF-I stimulates glucose transport in rat bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also about enhancing glucose uptake. Defects in IGF1 / IGF-I are the cause of insulin-like growth factor I deficiency (IGF1 deficiency) which is an autosomal recessive disorder characterized by growth retardation, sensorineural deafness, and mental retardation. |
Fig.Human IGF1 Protein