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产品型号:Mouse BMP-4 Protein, His tag
更新时间:2025-06-23
厂商性质:生产厂家
访问量:98
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产品英文名称 | Mouse BMP-4 Protein, His tag |
产品中文名称 | 重组小鼠骨形态发生蛋白4,His-标签(BMP-4) |
别名 | bone morphogenetic protein 4, BMP-2B, DVR4, BMP4 |
表达宿主 | 大肠杆菌 |
种属 | 小鼠 |
序列 | 氨基酸序列来源于:小鼠BMP-4 (P21275) (Lys303-Arg408)表达的蛋白片段。 |
活性 | Testing in progress. |
蛋白长度 | 重组小鼠BMP-4由106个氨基酸组成,预测分子量为12.1KD。 |
纯度 | > 98% ,使用SDS-PAGE检测 |
特点&优势 | 通过LAL法测定,每微克蛋白里内毒素含量<0.1>0.1> |
产品形式 | 冻干粉,冻干缓冲液为无菌的PBS,pH 4.0。 |
基因ID | 12159 |
蛋白序列链接 | /uniprotkb/P21275/entry#sequences |
使用中注意事项 | 开盖使用前,请先离心。本产品为冻干粉,推荐用该产品配套的Reconstitution Buffer进行复溶,且浓度不低于100 µg/mL。客户可根据后续的实验需求,进行进一步的稀释。 |
保存建议 | 本产品为冻干粉形式,建议:将冻干粉产品保存于-20℃以下的干燥环境中。本产品溶解之后,可在4℃保存2-7天,长期使用请置于-20℃以下。为长期保存,推荐添加载体蛋白(0.1% HSA或者BSA),并酌情分装保存,避免反复冻融。 |
运输条件 | 冰袋运输(蓝冰) |
警告 | 本文列出的产品仅供研究使用,不适用于人类或临床诊断。我们产品所推荐应用,不是建议使用我们的产品去违反任何或许可证。对于使用本产品可能发生的侵权或其他违规行为,我们不承担任何责任。 |
背景 | Bone morphogenetic protein 4 (BMP4) is a multifunctional ligand protein belonging to TGF β Family. BMP4 is expressed by endothelial cells (EC) in response to hypoxia and promotes proliferation of vascular smooth muscle cells (SMC). For example, it inhibits the proliferation of SMCs isolated from the proximal pulmonary artery while inducing the proliferation of SMCs isolated from the distal pulmonary artery. BMP4 seems to be a marker and driver of vascular calcification, especially in atherosclerosis. BMP4 induces angiogenesis, endothelial cell (EC) proliferation, and migration. BMP4 is differentially expressed in calcified atherosclerotic plaque, which is the junction between atherosclerotic vascular calcification and normal bone formation mechanism. BMP4 increases plaque formation, promotes oxidative stress, endothelial dysfunction and osteogenic differentiation through its proinflammatory and atherogenic effects. |
Fig.Mouse BMP-4 Protein, His tag